Fipronil: sanitary and agricultural insecticide

Cockroaches have been living side by side with humans for centuries. Until the 18th century, Europe was familiar only with black individuals called Prussians.

Thanks to transit from America, we also got red cockroaches, which significantly displaced their black counterparts.


Red cockroach

These insects don’t look too nice, but that’s far from the worst thing.

They are capable of carrying serious diseases:

  • gastroenteritis;
  • diarrhea;
  • dysentery.

When molting, their chitinous cover is destroyed, its remains cause allergic reactions. It is not easy to remove these insects. You can't do without pesticides here. Many people successfully use Fipronil against cockroaches: a description of the active substance and reviews of drugs based on it will help you choose the right way to fight them.

You may be interested in our other article on the same topic: Where do cockroaches come from in an apartment: how insects choose a home

fipronil: basic information about the pesticide

Description: The insecticide used to control a wide range of pests, including thrips, rootworms, wireworms, weevils and termites.

Year of official registration: 1993

Release of pesticides onto the market (Directive 91/414/EEC), status:

StatusAnnex 1
Speaker/co-speaker dossierFrance
The enable date is about to expire30/09/2017

Approved (V) or known (#) in the following European countries:

V V V V V V V V V V V

Also registered in: Australia, USA

Basic information:

Type of pesticideInsecticide, Veterinary drug
Chemical Structure GroupPhenylpyrazoles
Nature of actionWide spectrum with contact and stomach action. GABA-missing chloride channel antagonist.
CAS registration number120068-37-3
Code CF (Enzyme Code)424-610-5
International Cooperative Pesticide Review Council (CIPAC) code581
US Environmental Protection Agency (US EPA) Chemical Code
Chemical formulaC12H4Cl2F6N4OS
SMILESFC(F)(F)S(=O)c2c(C#N)nn(c1c(Cl)cc(cc1Cl)C(F)(F)F)c2N
International Chemical Identifier (InChI) InChI=1/C12H4Cl2F6N4OS/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7(3-21)23-24) 26(25)12(18,19)20/h1-2H,22H2
Structural formula

Molecular weight (g/mol)437.15
IUPAC name 5-amino-1-(2,6-dichloro-α,α,α-trifluoro-p-tolyl)-4-trifluoromethylsulfinylpyrazole-3-carbonitrile
CAS name 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile
Other information
Herbicide resistance according to HRACNot determined
Insecticide resistance according to IRAC2B
Fungicide resistance according to FRACNot determined
Physical stateWhite powder

Release:

IndexMeaning
Pesticide Manufacturers
  • BASF
  • Certis
  • Bayer
  • Kingtai Chemicals
Commercial names of drugs containing a.v.
  • Regent
  • Adonis
  • Space
Associated with this substance:
Assessing the risk of a pesticide to the local environment (England)No
Preparative form and application featuresOften supplied as fine granules that are dissolved in water and used as a compost treatment or starter.

Popular remedies for cockroaches with Fipronil

Despite the fact that Fipronil was invented in France, at the moment the largest German concern BASF is the holder of full patent rights to manufacture and sell products in Russia and many other countries.

In different countries, Fipronil-based insecticides can be found under the following names:

  1. Gel against cockroaches "Hector";
  2. Regent;
  3. Goliath;
  4. Termidor;
  5. Combat Ant-Rid;
  6. Baron.

Quite a few products are available in the form of gels: Domovoy Proshka, Kapkan; Combat Super gel, Eslanadez.

Let's talk about some of them in more detail.

Gel bait against cockroaches "Hector"

Gel bait (syringe) "Gektor" has a fipronil concentration of 0.05% in its composition! This gel can quickly exterminate pests such as cockroaches. Self-treatment of a room with gel is a big blow for all cockroaches and does not create inconvenience in the form of an unpleasant odor or wet surfaces as after the work of exterminators. The long-term effect of the gel makes it impossible for newborn insects to survive.

The gel is considered effective until it dries completely! In rooms with high humidity, the gel retains its properties much longer!

Hector gel can attract cockroaches within a radius of up to 1 meter. No matter what the insect ate before, it will definitely eat this toxic gel.

After the cockroach is poisoned, it will be able to penetrate the nest of its fellow tribesmen and infect them there. When contacting infected cockroaches, their healthy “relatives” can also become infected.

You can simply lightly touch the cockroach with Hector gel to infect it. Infected insects cannot expand their species. As a result, the entire group of cockroaches will die out.


Gel against cockroaches "Hector"

The Hector gel treatment method for cockroaches is as follows:

  • First, remove the cap from the syringe tip;
  • Then press the tip of the syringe onto the surface to be treated;
  • Gently squeeze a small amount of gel, no more than 1 ml, onto the surface. (the size of a small “drop”);
  • The consumption should be 4 drops per square meter;
  • After use, wash your hands thoroughly with soap and water.

When processing, pay attention to the following areas:

  • Along and inside the baseboards;
  • Behind the door panels;
  • The back surface of cabinets, refrigerators, stoves;
  • Gaps between shelves and walls;
  • In ventilation;
  • Behind the sink;
  • Under the bath;
  • Areas behind and under furniture;
  • Near the trash container;
  • Behind the peeled wallpaper.

Spray Baron

This product is available in the form of bottles with a volume of 100 ml.


Spray Baron against cockroaches

Active ingredient - Fipronil has a concentration of 0.3%. This is quite a bit, but quite enough to effectively kill insects.

After treatment, even a large colony of cockroaches will die within a week.


Places where cockroaches can hide in the kitchen

The can is convenient to use. Spraying is carried out from a distance of 20-25 cm from the surface to be treated.

The areas where cockroaches most often accumulate are sprayed most thoroughly:

  • under and behind the kitchen stove;
  • along the perimeter at the bottom of the refrigerator;
  • under the sink;
  • where the trash can is located;
  • next to the microwave;
  • under the bathtub and sink;
  • next to the ventilation holes and inspection hatch;
  • baseboards in the hallway;
  • in the area of ​​the entrance door along its entire perimeter, including platbands.

Sometimes a single treatment is enough, but to get the result for sure, it is better to repeat the procedure after one or two weeks, this will kill the young individuals that hatched during this time.

To kill cockroaches in an apartment of 50 square meters, just one can of Baron is enough.

You may also be interested in our other article: Where do cockroaches hide, what places in the apartment should you pay close attention to?

Regent

This insecticide is produced by French.

One package contains 0.5 g of water-dispersible, i.e. water-soluble granules.


Packaging of the drug Regent

One bottle contains 100 g of the drug. The concentration of Fipronil is 800 g per kilogram of the drug.

Initially, the product was intended to destroy Colorado potato beetles. As it turned out, it also copes well with cockroaches.

If there is a large concentration of insects, prepare a concentrated solution, for which one sachet of the product is diluted in 250 ml of water. For preventive treatments, it is enough to dilute the bag in 2 liters of water.

This substance has a second class of hazard to humans, so precautions when working with it must be very strict.

  1. Animals and children are removed from the apartment.
  2. Use a respirator and safety glasses.
  3. Wear thick clothing and gloves on your hands.

After treating the apartment, you cannot stay in it for 3 hours. All this time the windows must be open.

A mandatory stage of processing is final wet cleaning using a salt solution.

This effective drug has several undeniable advantages:

  • economical consumption;
  • no odor;
  • safety for the interior - it does not damage wallpaper or upholstery.

Gel Eslanadez

This domestic product in the form of a gel is very convenient to use.

It successfully combines 2 effective insecticides:

  1. Fipronil at a concentration of 0.03%;
  2. Imidacloprid at a concentration of 0.5%.

In addition to them, the composition includes gelling agents, a preservative and stabilizer, and sugar. The bitter substance Bitrix, specially included in the composition, will not be to the taste of pets, this will protect them from poisoning.

The gel has an intestinal-contact effect, guaranteeing effective destruction of insects.


Eslandez gel

The protection period is very long - up to 2 months. It is gratifying to note that the gel has only a 4th class of hazard for humans and is considered a low-hazard substance.

The product is available in the form of a syringe containing from 20 to 50 ml of gel. Tubes with a convenient tip contain from 30 to 75 g of the substance.

The gel is a colorless and sometimes white substance, which may have a yellowish tint. Due to its sugar content, the gel is very attractive to cockroaches.

Imidacloprid and Fipronil against cockroaches in the form of a gel are used as follows.

  • They clean thoroughly, leaving not a crumb of food behind.
  • Squeeze out a thin layer of gel 2 cm long in the form of a dotted line in places where insects accumulate.
  • If there are few of them, the distance between the gel strips can be 4 cm. If there are a large number of cockroaches, this can be reduced.
  • It is allowed to apply the product to the substrate.

It is especially convenient for use in places that are not accessible to other processing methods.

You can reapply the gel after 2 weeks. This is usually not necessary, since the mortality rate of insects from Eslanadez gel is very high - up to 95%.

Review: Eslanadez anti-cockroach gel, how to use and how effective the drug is

Conclusion

The fight against cockroaches is quite difficult, especially if there is a constant source of their possible appearance - living in a neighboring apartment or the presence of a catering establishment in the house.

In this case, not only immediate actions to destroy insects are important, but also constant prevention of their appearance. Correctly selected and effective Fipronil-based products will help you cope with the problem.

fipronil: behavior in the environment

IndexMeaningSource / Qualitative indicators / Other informationExplanation
Solubility in water at 20oC (mg/l)3.78A5Short
Solubility in organic solvents at 20oC (mg/l)28A5 - Hexane
3000A5 - Toluene
137500A5 - Methanol
545900A5 - Acetone
Melting point (oC)203A5
Boiling point (oC)Decomposes to a boilA5
Decomposition temperature (oC)230A5
Flash point (oC)Fire hazard is not highA5
Partition coefficient in the octanol/water system at pH 7, 20oCP:5.62 X 1003Calculated
Log P:3.75A5High
Specific Gravity (g/ml) / Specific Gravity1.71A5
Dissociation constant (pKa) at 25oCNot determinedA5
Note: does not dissociate
Vapor pressure at 25oC (MPa)0.002A5Volatile
Henry's law constant at 25oC (Pa*m3/mol)2.31 X 10-04A5Not volatile
Henry's law constant at 20oC (dimensionless)1.60 X 10-07Q2Not volatile
Decay period in soil (days)DT50 (typical)142A5Stable
DT50 (laboratory at 20oC):142A5Stable
DT50 (field):65A5Medium stable
DT90 (laboratory at 20oC):
DT90 (field):
Note:According to laboratory studies of the European Union, DT50 is 32-346 days, geometric mean 142, in field conditions range 5.6-135 days 4 European sites; Other sources: 96 days (DW4)
Aqueous photolysis DT50 (days) at pH 7Meaning:0.33B5Fast
Note:Rapid in artificial light
Aqueous hydrolysis DT50 (days) at 20oC and pH 7Meaning:StableA5Very resistant
Note:Stable at pH 5 to 7, some hydrolysis occurs at pH 9 - DT50 approximately 11 days at oC
Water deposition DT50 (days)68A5Medium fast
Only aqueous phase DT50 (days)54A5Stable
Potential leaching index GUS2.67CalculatedTransition state
Index of increase in concentration in groundwater SCI (µg/l) at an application dose of 1 kg/ha (l/ha)Meaning:2.09 X 10-01Calculated
Note:
Potential for particle bound transport indexCalculatedAverage
Koc - organic carbon partition coefficient (ml/g)577B5Poorly mobile
pH stability: No
Note: EU dossier range 427-727, 5 soil mL/g; Other sources: 838 mL/g (DW4)
Freundlich adsorption isothermKf:11.85A5
1/n:0.95
NoteMean of 5 Meanings. Sandy loam OC=0.34% pH=6.1 Kf=4.19; Loam OC=4.25 pH=6.9 Kf=20.7; Loamy sand OC=3.35% pH=6.3 Kf=14.3; Clay loam OC=1.4% pH=6.3 Kf=10.03
Maximum UV absorption (l/(mol*cm))[3nm=48385; 6nm=7281, 1nm=6008] A5

The main products of pesticide decomposition:

MetaboliteEducation environmentEstimated maximum fraction distributionCompliance with Directive 91/414
fipronil amide (Ref: RPA 200766)the soil0.384main decomposition product, corresponds to
fipronil sulfone (Ref: MB-46136)the soil0.343main decomposition product, corresponds to
fipronil sulfide (Ref: MB-45950)the soil0.170main decomposition product, corresponds to

Other known pesticide degradation products:

Decomposition product name and linkOther namesEducational environment/levelEstimated maximum fraction distribution
5-amino-1-(2,6-dichloro-alpha,alpha,alpha-trifluoro-p-tolyl)-1H-pyrazole-3-carbonitrile (Ref: MB 45897)Rat
5-amino-1-(2,6-dichloro-alpha,alpha,alpha-trifluoro-p-tolyl)-4-trifluoro-methylpyrazole-3-carbonitrile (Ref: MB 46513)soil (Photolysis, Aerobic); Water; Plant
Note: Low mobility
5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl) pyrazole-4-sulfonic acid, potassium (Ref: RPA 104615)soil (Photolysis); Plant
Note: Rat oral LD50 > 2000 mg/kg bw
1-(2,6-dichloro-4-trifluoromethylphenyl)-3-amino-5-amino-4-trifluoromethylsulfonylpyrazole (Ref: RPA 105048)Water
Note: Rat oral LD50 467 mg/kg bw
5-amino-3-carbamyl-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-rifluoromethylsulfonylpyrazole (Ref: RPA 105320)Plant
Note: Rat oral LD50 > 2000 mg/kg bw
5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfonylpyrazole-3-carboxylic acid (Ref: RPA 200761)soil (Aerobic); Plant
Note: Resistant

Fipronil contamination of eggs, 2022[edit]

Main article: Fipronil contamination of eggs 2022

The 2022 fipronil egg contamination is an incident in Europe and South Korea involving the spread of eggs and egg products contaminated with insecticides. Chicken eggs have been found to contain fipronil and are distributed in 15 European Union countries, Switzerland and Hong Kong. [34] [35] It is believed that around 700,000 eggs were put on the shelves in the UK alone. [36] Eggs from 44 farms in Taiwan were also found to have excessive levels of fipronil. [37]

fipronil: ecotoxicity

IndexMeaningSource / Qualitative indicators / Other informationExplanation
Bioconcentration factorBCF:321A5 All fishThreshold for concern
CT50 (days):3
Bioaccumulation potentialCalculatedModerately
Mammals - Acute oral LD50 (mg/kg)92B5 RatHigh
Mammals - Short-term food NOEL(mg/kg):0.35A5 RatHigh
(ppm food):
Birds - Acute LD50 (mg/kg)11.3B5 Virginia quailHigh
Birds - Acute toxicity (CK50 / LD50)
Fish – Acute 96 hour CK50 (mg/l)0.248A5 Rainbow troutModerately
Fish - Chronic 21 day NOEC (mg/l)0.015A5 Rainbow trout
Aquatic invertebrates - Acute 48 hour EC50 (mg/l)0.19B5 Daphnia magna (Daphnia major, Large water flea)Moderately
Aquatic Invertebrates - Chronic 21 day NOEC (mg/L)0.068A5 Daphnia magna (Daphnia major, Large water flea)
Aquatic crustaceans - Acute 96 hour CK50 (mg/l)0.00014A5 Mysis shrimpHigh
Bottom microorganisms - Acute 96 hour CK50 (mg/l)
Bottom microorganisms - Chronic 28 day NOEC, static, Water (mg/l)0.0001A5 Chironomus mosquitoHigh
Benthic microorganisms - Chronic 28 day NOEC, Sediment (mg/kg)0.0002A5 Chironomus mosquitoHigh
Aquatic plants - Acute 7 day EC50, biomass (mg/l)0.16A5 DuckweedModerately
Algae - Acute 72 hour EC50, growth (mg/l)0.068A5 Green algae (Scenedesmus subspicatus)Moderately
Algae - Chronic 96 hour NOEC, growth (mg/l)
Bees - Acute 48 hour LD50 (µg/individual)0.00417B5 OralHigh
Soil worms - Acute 14-day CK50 (mg/kg)> 500A5 Earthworm
, corr
Moderately
Soil Worms - Chronic 14-Day Maximum Non-Effective Concentration, Reproduction (mg/kg)500A5 Earthworm
, corr
Short
Other soil macroorganisms, such as springtailsLR50 / EC50 / NOEC / Action (%)0.32A5 Tropical white springtail (Folsomia candida)
, EC50 Reproduction mg/kg
Other Arthropods (1)LR50 (g/ha):0.0148 hour A5 Rider (imago)Harmfulness at 1 kg/ha
Action (%):
Other Arthropods (2)LR50 (g/ha):0.101Day 7 A5 Predatory miteHarmfulness at 1 kg/ha
Action (%):
Soil microorganismsNitrogen mineralization: no significant effect Carbon mineralization: no significant effectA5 [Dose: 0.67 mg/ha soil, 28 days]
Available data on the mesoworld (mesocosm)NOEAEC mg/l:
NOEAEC mg/l:

Side effects

Fipronil has low (grade 2) dermal toxicity and moderate (grade 3) oral and inhalation toxicity. When applying the drug to the dermis, short-term skin reactions may occur: redness, itching, rashes, loss of fur at the site of application.

If the drug enters the intestines, symptoms of neurotoxic damage may occur:

  • tremor of the limbs;
  • vomit;
  • increased salivation;
  • convulsions;
  • abnormal gait;
  • depression;
  • increased nervousness;
  • hunched over.

The same signs may appear when Fipronil is inhaled if the spray is handled carelessly. In case of severe poisoning, lethargy, convulsions and death of the animal may occur. It has been found that dogs are more sensitive to the substance than cats.

An overdose can also provoke an allergic reaction, breathing problems, and heart palpitations. Symptoms of poisoning can be eliminated by administering barbiturates.

fipronil: human health

Basic indicators:

IndexMeaningSource / Qualitative indicators / Other informationExplanation
Mammals - Acute oral LD50 (mg/kg)92B5 RatHigh
Mammals - Skin LD50 (mg/kg body weight)354A5 Rabbit
Mammals - Inhalation CK50 (mg/l)0.36A5 Rat
ADI - permissible daily dose (mg/kg body weight per day)0.0002A5 Dog, SF=100
ARfD - average daily intake (mg/kg body weight per day)0.009A5 Rat, SF=100
AOEL - acceptable systemic operator exposure level0.0035A5 Dog, SF=100
Skin absorption (%)1.0A5
Hazardous Substances Directive 76/464/ECList II
Types of restrictions
by categoryAre common:
Professional:
Examples of European MRLs (mg/kg)Meaning:Maize, sunflower grains and sweetcorn: 0.05
Note:[A5 EU dossier proposals]
MPC in drinking water (µg/l)

Toxicological and hygienic characteristics:

? ? X V V V
Effect on humans[Thyroid, kidney and liver poison], [Very toxic], [Bioaccumulates]

V: Yes, it is known what causes it X: No, it is known what does not cause it? : Possibly, not exactly determined - : No data

Legislation:

IndexMeaningSource / Qualitative indicators / Other informationExplanation
Basics[Doesn't explode],
European Commission Risk Classification,
European Commission safety classificationS1/2, S28, S36/37, S45, S60, S61
WHO classificationIIModerately dangerous
US Environmental Protection Agency (US EPA) classificationIIWarning—
UN Number2588
Packaging and disposal[Usually packaged in Group III (minor hazard) containers]

Action

Fipronil is a neurotoxin (nerve poison) of intestinal and contact action. In animals, it binds to γ-aminobutyric acid (GABA), the most important mediator (regulator) of the passage of nerve impulses through the chlorion channels of nerve cell membranes. Without the mediator “turned off” by fipronil, the nervous system becomes overexcited to the point of convulsions, followed by a reaction - paralysis and death.

The specific mechanisms of transmission of nerve impulses to muscles in different groups of animals are significantly different. Fipronil is quite highly selective against insects, incl. resistant to carbamates, pyrethroids and FOS. However, the objects of elimination develop tolerance to this substance, therefore, in agricultural technology, pesticides with fipronil are used in rotation to avoid resistance of pests or occasionally during their mass invasion. In the fight against resistance, fipronil is used as a replacement drug, because actively accumulates in plants, and moves along the soil profile slowly and to a depth of no more than 30 cm.

The speed of action of fipronil as an agrotechnical insecticide is low - the death of insects begins 8-10 hours after treatment. The effectiveness is also not 100% - after a day, up to 15% of pests survive. However, the protective effect is long-lasting, 14 days or more, and the drug is not washed off by rain. Therefore, on land areas, fipronil is most effective against massively migrating pests: when the density of individuals and the total volume of the wandering mass decreases below a certain limit, it stops migrating, and the surviving individuals scatter across the area and, “not feeling the shoulder of their fellows,” quickly die, leaving no offspring, like ants isolated from an anthill.

Note : Since 2003, fipronil has been recommended by the FAO (Food and Agriculture Organization of the United Nations) as the primary control agent for desert locust infestations.

Insecticide "Brownie Proshka"

Gel "Proshka Domovoy" showed high efficiency

This product may seem unsightly, and it is not at all advertised. But it is worth noting that the drug is domestically produced, comes in a convenient gel form, and contains a high percentage of such an effective substance as fipronil against cockroaches. By purchasing this gel, you already receive a ready-made bait, which you only need to apply at home to the expected places of movement of pests.

“Domovoy Proshka” has many advantages: it contains the effective component fipronil, the product is convenient to distribute and apply, has a low cost, but is of good quality. But when working with any insecticides, do not forget about the rules of personal safety.

Fipronil is a toxic substance that is included in many effective drugs for killing various household pests. Due to its high toxicity, the drug cannot be used to treat rooms where children or pets live. Often, if you work carelessly with fipronil, a person experiences headaches, nausea, dizziness and skin irritation.

Reviews from owners and veterinarians

Ekaterina, 45 years old, Murmansk: “A cat and a dog live in my apartment. Bobik and I often walk in the forest belt and go into nature, so we need a strong anti-tick remedy. Marusya stays at home, but she can become infected with insects from the dog.

Instead of drops, I decided to try Fipronil spray. It is not only effective, but also economical. For 2 adult animals, a 250 ml bottle is enough for 4 treatments.”

Vladimir, 32 years old, Moscow region: “I live in my own house. That's why my 2 cats roam freely around the yard. Last year it was a hot summer and the fleas were overwhelming. I had to look for a good, reliable product with a prolonged effect.

At first I bought Fipronil drops, but the seller recommended a spray. There is much more of it and you can treat your pets during the entire period of flea and tick activity. I bought a 100 ml container. There’s even left for next year.”

Olga, 23 years old, Nikolaev: “3 kittens were dropped off at my place of work. We took them home. The babies were heavily infested with fleas. I washed them with special shampoos, tar soap, and combed them. But after a while they appeared again.

On the advice of the veterinarian, I dropped a few drops of Fipronil onto the withers. The kitten was approximately 2-3 months old. I watched the reaction for 24 hours, but everything turned out okay. But I didn’t see any more fleas.”

Kaleria, veterinarian, Tambov: “I use insecticides with fipronil myself to treat pets and recommend them to my clients. If you follow the rules of use, the product is safe, effective and relatively inexpensive.”

Sergey, veterinarian, Vladimir: “For fleas and ticks, I recommend Fipronil spray. It is capable of killing adult parasites and their larvae. The spray is convenient to use for treating cat beds, but after that they need to be thoroughly ventilated and fried in the sun. I recommend testing for an allergic reaction before use so that you don’t have to treat your pet later.”

Instructions for use

Fipronil is included in a variety of drugs, each of which has its own purpose, so there are no universal instructions for it - in each specific case you must follow the instructions provided by the manufacturer. The only condition common to all drugs is compliance with standard safety measures:

  1. While working with the substance, drinking, smoking and eating are prohibited. The face should be protected with a special mask, hands with gloves, and body with tight-fitting clothing to prevent the drug from coming into contact with exposed skin.


    Take precautions when treating with Fipronil to avoid poisoning

  2. The dishes that were used to prepare the working solution should not subsequently be mixed with kitchen utensils.
  3. Fipronil should not be used near ponds or aquariums. During treatment, there should be no small children or pregnant women nearby. If the drug is used as part of a food bait, the latter is positioned so that the child cannot reach it.
  4. At the slightest symptoms of poisoning (dizziness, nausea, vomiting, general weakness, etc.), you should immediately consult a doctor.

Anti-flea products with Fipronil are contraindicated for puppies and kittens under two months of age, as well as adult animals with weakened immune systems.

The substance has the first and third classes of danger for pollinating insects (depending on the purpose of the drug, which includes Fipronil). Hazard classes for humans - second and third.

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